Marius was the older half- brother of Valerie who had manipulated her by forcing her to overuse her Longinus by modifying numerous Vampires of the Tepes Faction and reviving the Evil Dragons, resulting in her former broken state of overusing the Sephiroth Graal. He had shown little to no apparent concern for her well-being, caring more for her value as a Longinus wielder. Ultimately, Marius was completely cruel to the point that he was willing to commit sororicide by extracting the Sephiroth Graal from Valerie's body to claim her Longinus as his own, despite knowing the process would kill her. After acquiring one of Valerie's Sephiroth Graal's, Marius took immense joy and excitement and did not show guilt in putting Valerie's life in danger.
Gasper is the longtime childhood friend of Valerie. Valerie has shown great care for Gasper, even when she has been bedridden from the overuse of her Longinus. She is also both glad and saddened at Gasper's growth; happiness at his growth as a man and sadness for missing it. It was Valerie who got Gasper into cross-dressing, as she would often dress him up in her clothing in the past.
She and Issei have shown to be on good terms with each other, as shown in volume 20 when she comforted Issei when he was being worried about Ravel.